Small Dense LDL: New Marker for Cardiovascular Risk Assessment and its Therapeutic Inflection
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چکیده
منابع مشابه
Small Dense LDL: New Marker for Cardiovascular Risk Assessment and its Therapeutic Inflection
Cardiovascular diseases (CVD) encompass any medical conditions related to the heart and blood vessels. CVD is the main cause of disability and premature death worldwide, and is projected to remain the leading cause of death. An estimated 17.5 million people died from this disease in 2005, representing 30% of all global deaths. Of these deaths, 7.6 million were due to coronary heart disease (CHD...
متن کاملSmall dense LDL: risk factor for coronary artery disease (CAD) and its therapeutic modulation.
Pathogenesis of coronary artery disease (CAD) is multi-factorial and many risk factors are associated with development of CAD. LDL-C has been an important target for therapeutic interventions and has been extensively studied. But, various studies have indicated that estimation of LDL-C is not enough to assess the risk. Moreover, LDL particles vary in their content, density and size which have d...
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OBJECTIVES To examine whether the lipid parameters are predicting factors for human immunodeficiency virus (HIV)-associated lipodystrophy. METHODS Whole-body fat compositions of HIV-positive patients receiving stavudine-containing antiretroviral regimens (n = 79) were determined. Lipodystrophy was defined as a ratio of trunk fat mass/lower limb fat mass greater than 2.28. Blood samples were a...
متن کاملLipoprotein(a): A Promising Marker for Residual Cardiovascular Risk Assessment
Atherosclerotic cardiovascular diseases (CVD) are still the leading cause of morbidity and mortality worldwide, although optimal medical therapy has been prescribed for primary and secondary preventions. Residual cardiovascular risk for some population groups is still considerably high although target low density lipoprotein-cholesterol (LDL-C) level has been achieved. During the past few decad...
متن کاملLipoprotein-associated phospholipase A2 activity is a marker of small, dense LDL particles in human plasma.
BACKGROUND Recent clinical studies showed that lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a predictor for incident atherosclerotic disease. We have previously shown that among the LDL subfractions, Lp-PLA(2) activity is preferentially associated with the atherogenic small, dense (sdLDL) particles in vitro. We investigated whether Lp-PLA(2) could be a marker of sdLDL in human plasm...
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ژورنال
عنوان ژورنال: Biochemistry & Analytical Biochemistry
سال: 2012
ISSN: 2161-1009
DOI: 10.4172/2161-1009.1000e118